Search Result

Results for "

M. tuberculosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (14) Antifolate (1) Apoptosis (1) Autophagy (2) Bacterial (84) Calcium Channel (3) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (4) Drug Metabolite (3) Endogenous Metabolite (1) Fungal (8) Interleukin Related (1) Isotope-Labeled Compounds (2) MMP (1) P-glycoprotein (3) Parasite (2) Potassium Channel (1) PROTACs (2) Proton Pump (1) TGF-beta/Smad (1) Thymidylate Synthase (5) TNF Receptor (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (4) Infection (91) Inflammation/Immunology (11) Metabolic Disease (1)

By Targets:

Akt (1)

Antibiotic (14)

Antifolate (1)

Apoptosis (1)

Autophagy (2)

Bacterial (84)

Calcium Channel (3)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (4)

Drug Metabolite (3)

Endogenous Metabolite (1)

Fungal (8)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

MMP (1)

P-glycoprotein (3)

Parasite (2)

Potassium Channel (1)

PROTACs (2)

Proton Pump (1)

TGF-beta/Smad (1)

Thymidylate Synthase (5)

TNF Receptor (2)

By Research Areas:

Cancer (5)

Cardiovascular Disease (4)

Infection (91)

Inflammation/Immunology (11)

Metabolic Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139618

Dup-721	Bacterial Antibiotic	Infection
DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis .

HY-124814

C215	Bacterial	Infection
C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC₉₀ of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages .

HY-162142

BB2-50F	Bacterial	Infection
BB2-50F is a potent and multi-targeting bioenergetic bactericidal inhibitor of M. tuberculosis and can sterilizes replicating and non-replicating M. tuberculosis. BB2-50F inhibits succinate oxidation, decreases the activity of the tricarboxylic acid (TCA) cycle, and results in succinate secretion from M. tuberculosis.

HY-134648

Ganfeborole GSK656 free base; GSK3036656 free base; GSK070 free base	Bacterial	Infection
Ganfeborole (GSK656 free base) is a potent, selective and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase, with an IC₅₀ of 0.20 μM. Ganfeborole can be used for the research of tuberculosis .

HY-153572

Homo-BacPROTAC7

PROTACs Bacterial Infection

Homo-BacPROTAC7 is a ClpC1_NTD BacPROTAC degrader and can targets ClpC2. Homo-BacPROTAC7 efficiently kill M. tuberculosis .

Homo-BacPROTAC7	PROTACs Bacterial	Infection
Homo-BacPROTAC7 is a ClpC1_NTD BacPROTAC degrader and can targets ClpC2. Homo-BacPROTAC7 efficiently kill M. tuberculosis .

HY-150967

MmpL3-IN-1	Bacterial	Infection
MmpL3-IN-1 (compound 32) is a potent Mycobacterial membrane protein large 3 (MmpL3) inhibitor. MmpL3-IN-1 has anti-tuberculosis activity with the MIC<0.016 μg/mL in M. tuberculosis and can be used in studies of drug-resistant tuberculosis .

HY-146055

Antituberculosis agent-1

Bacterial Infection

Antituberculosis agent-1 (Compound 8a) is an antituberculosis agent with an MIC of 3.84 µg/mL against M. tuberculosis H₃₇R_v .

Antituberculosis agent-1	Bacterial	Infection
Antituberculosis agent-1 (Compound 8a) is an antituberculosis agent with an MIC of 3.84 µg/mL against M. tuberculosis H₃₇R_v .

HY-146104

Antimycobacterial agent-1	Bacterial	Infection
Antimycobacterial agent-1 (compound 33) has selectively antimycobacterial activity against *Mycobacterium tuberculosis* (M. tuberculosis) H37Ra with a MIC** value of 1 μg/ml. Antimycobacterial agent-1 has relatively low cytotoxicity in normal cells (Vero cells IC₅₀ = 143.2 μg/ml) .

HY-151514

Antituberculosis agent-5	Bacterial	Infection
Antituberculosis agent-5 (compound 52) is a nitrofuranylamide derivative, inhibits M. tuberculosis UDP-Gal mutase. Antituberculosis agent-5 inhibits Glf activity with an IC₅₀ value of 99 μM/mL and resists tuberculosis (TB) with a MIC value of 1.6 μg/mL .

HY-129943

Benzothiohydrazide	Bacterial	Infection
Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC₁ and IC₂) .

HY-156412

DHFR-IN-10	Bacterial	Infection
DHFR-IN-10 (compound 4c) is a potent DHFR inhibitor, with an IC₅₀ of 4.21 μM for M. tuberculosis DHFR enzyme. DHFR-IN-10 exhibits potent antituberculosis efficiency .

HY-146119

Antitubercular agent-24	Bacterial	Infection
Antitubercular agent-24 (Compound 1) is an anti-tubercular agent with an extracellular IC₅₀ of 0.83 μM and an intracellular IC₅₀ of 0.17 μM against *M. tuberculosis* H37Rv** .

HY-156414

DHFR-IN-11	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-11 (compound 6b) is inhibitor of DHFR, and has inhibitory potency versus M. tuberculosis DHFR enzyme with IC₅₀ values 5.70 μM .

HY-136348

ML338	Bacterial	Infection
ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis* bacilli* and is against the non-replicating M. tuberculosis with IC₉₀ and IC₉₉ values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy .

HY-B0271

Pyrazinamide 1 Publications Verification Pyrazinecarboxamide; Pyrazinoic acid amide	Bacterial Autophagy Antibiotic	Infection
Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-151205

Antituberculosis agent-3	Bacterial	Infection Inflammation/Immunology
Antituberculosis agent-3 (Compound 2) is an antituberculosis agent. Antituberculosis agent-3 shows anti-mycobacterial activity, and can inhibit M. tuberculosis H37Rv strain growth (MIC=12.5 μg/mL) .

HY-151339

Antitubercular agent-31	Bacterial	Infection
Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC₅₀ of 1.1 μM .

HY-N12600

Thiolopyrrolone A	Bacterial	Infection
Thiolopyrrolone A (compound 1) exhibits antibacterial activities against BCG, M. tuberculosis and S. aureus with minimum inhibitory concentrations (MIC) of 10, 10 and 100 μg/mL, respectively .

HY-151204

PknB-IN-1	Bacterial	Infection Inflammation/Immunology
PknB-IN-1 (Compound 2) is a protein kinase B (PknB) inhibitor (IC₅₀=14.4 μM). PknB-IN-1 shows anti-mycobacterial activity, can inhibit M. tuberculosis H37Rv strain growth (MIC=6.2 μg/mL) .

HY-146098

Antibacterial agent 105	Bacterial Antibiotic	Infection
Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones show antibacterial activity against M. tuberculosis with antibacterial activity (MIC₉₀=2.64 μM)。Antibacterial agent 105 exhibits antibacterial activities against different bacterial species with MIC₉₀s of 11.18, 11.18，0.70，1.40，44.70, and 22.35 μM for M. smegmatis, M. aurum, M. marinum,BCG, E. aerogenes and S. aureus, respectively .

HY-139987

LeuRS-IN-1	Bacterial	Infection
LeuRS-IN-1 is a potent, orally active M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) inhibitor. LeuRS-IN-1 has IC₅₀ and Kd values of 0.06 μM, 0.075 μM for M.tb LeuRS, respectively . LeuRS-IN-1 inhibits human cytoplasmic LeuRS (IC₅₀=38.8 μM), and HepG2 protein synthesis (EC₅₀=19.6 μM) .

HY-139987A

LeuRS-IN-1 hydrochloride	Bacterial	Infection
LeuRS-IN-1 hydrochloride is a potent, orally active M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) inhibitor. LeuRS-IN-1 hydrochloride has IC₅₀ and Kd values of 0.06 μM, 0.075 μM for M.tb LeuRS, respectively . LeuRS-IN-1 hydrochloride inhibits human cytoplasmic LeuRS (IC₅₀=38.8 μM), and HepG2 protein synthesis (EC₅₀=19.6 μM) .

HY-151958

Antitubercular agent-35	Bacterial	Infection
Antitubercular agent-35 (compound 42l) is an antitubercular agent. Antitubercular agent-35 inhibits the growth of Mtb_H37Rv and *M. Marinum* with MIC₉₀ values of 1.25 and 2 μg/mL, respectively. Antitubercular agent-35 shows the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent-35 can be used for the research of tuberculosis .

HY-146120

Antitubercular agent-25	Bacterial	Infection
Antitubercular agent-25 (Compound 28) is an anti-tubercular agent with an extracellular IC₅₀ of 0.42 μM and an intracellular IC₅₀ of 0.20 μM against *M. tuberculosis* H37Rv**. Antitubercular agent-25 exhibits good metabolic stability .

HY-163033

Antitubercular agent-42	Bacterial	Infection
Antitubercular agent-42(19) is a selective fatty acyl-AMP ligase (FAAL) inhibitor (MIC₉₀ = 1.4 µg/mL for M. tuberculosis H37Rv). Antitubercular agent-42 shows antitubercular activity .

HY-N3612

Communic acid (+)-Communic acid	Bacterial Akt MMP	Infection Inflammation/Immunology
Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC₅₀ of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging .

HY-152136

Antituberculosis agent-6	Bacterial Fungal	Infection
Antituberculosis agent-6 (compound 9g) is a potent antimycobacterial agent. Antituberculosis agent-6 shows significant activity against M. tuberculosis, with a MIC of 3.49 μM. Antituberculosis agent-6 also shows good antifungal activity against A. niger, with a MIC of 62.50 μM. Antituberculosis agent-6 shows high GI absorption .

HY-149066

Diaporthein B	Bacterial	Infection Cancer
Diaporthein B is one of the most highly oxidized pimarane diterpenes. Diaporthein B exhibits activity against M. tuberculosis, with a MIC of 3.1 μg/mL. Diaporthein B reveals IC₅₀s of 1.5-3 μM against HCT 116 and LoVo colon cancer cells .

HY-152137

Antituberculosis agent-7	Bacterial Fungal Antibiotic	Infection Inflammation/Immunology
Antituberculosis agent-7, an oxetanyl-quinoline derivative, has shown good antibacterial activity against P. mirabilis with a MIC of 31.25 μM. Antituberculosis agent-7 shows good antifungal activity against A. niger with a MIC of 62.5 μM. Antituberculosis agent-7 shows excellent antimycobacterial activity with MIC 3.41 μM for M. tuberculosis H37Rv .

HY-152139

Antibacterial agent 129	Bacterial Fungal Antibiotic	Infection Inflammation/Immunology
Antibacterial agent 129, an oxetanyl-quinoline derivative, has shown good antibacterial activity against P. mirabilis and B. subtilis with MICs of 31.25 μM and 31.5 μM and . Antibacterial agent 129 shows good antifungal activity against A. niger with a MIC of 31.25 μM. Antibacterial agent 129 shows excellent antimycobacterial activity with MIC 57.73 μM for M. tuberculosis H37Rv .

HY-146121

Antitubercular agent-26	Bacterial	Infection
Antitubercular agent-26 (Compound 32) is an orally active anti-tubercular agent with an extracellular IC₅₀ of 0.50 μM and an intracellular IC₅₀ of 0.51 μM against *M. tuberculosis* H37Rv**. Antitubercular agent-26 shows good metabolic stability, low risk of cardiotoxicity and no genotoxicity .

HY-152138

Antituberculosis agent-8	Bacterial Fungal	Infection
Antituberculosis agent-8 (Compound 9i) is an antitubercular agent with an MIC of 3.53 μM (1.6 μg/mL) against **M. tuberculosis* H37Rv*. Antituberculosis agent-8 also shows good antifungal** activity against A. niger with an MIC of 62.50 μM .

HY-N11048

Amycolatopsin A	Bacterial	Infection Cancer
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC₅₀ values of 0.4 µM and 4.4 µM, respectively .

HY-124781

ML406	Bacterial Antibiotic	Infection
ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC₅₀ of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis .

HY-146699

MtTMPK-IN-5	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-5 (compound 17) is a potent *M. tuberculosis* thymidylate kinase (MtbTMPK) inhibitor with an IC₅₀** value of 34 μM. MtTMPK-IN-5 combines favorable enzyme inhibitory activity with significant activity against M. tuberculosis (MIC = 12.5 μM). MtTMPK-IN-5 can be used for researching tuberculosis .

HY-112702

CRS400393	Bacterial	Infection
CRS400393 is a potent antimycobacterial agent, with MIC of 0.03, 2, and ≤ 0.12 µg/mL against M. abs., M. avium, M. intracellulare, and M. tuberculosis, respectively .

HY-146700

MtTMPK-IN-6	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-6 (compound 1) is a potent *M. tuberculosis* thymidylate kinase (MtbTMPK) inhibitor with an IC₅₀** value of 29 μM. MtTMPK-IN-6 can be used for researching tuberculosis .

HY-147017

GSK2556286 GSK286	Bacterial	Infection Inflammation/Immunology
GSK2556286 (GSK286) is an orally active inhibitor of M. tuberculosis. GSK2556286 inhibits growth within human macrophages (IC50 = 0.07 μM). GSK2556286 is effective against both multidrug-resistant (MDR) or extensively drug-resistant (XDR) and agent-sensitive (DS) M. tuberculosis.

HY-147661

DHFR-IN-2	Antifolate	Infection
DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR (dihydrofolate reductase from M. tuberculosis), with an IC₅₀ of 7 μM. DHFR-IN-2 can be used for tuberculosis (TB) research .

HY-146373

Antibacterial agent 95	Bacterial	Infection
The minimum inhibitory concentration (MIC) of a new 2- (quinoline-4-methoxy) acetamide antituberculotic agent against the reference strain of Mycobacterium tuberculosis H37Rv was as low as 0.3 μ M. It also inhibited the growth of Mycobacterium tuberculosis in the macrophage model of tuberculosis infection.

HY-100725

BM212 3 Publications Verification	Bacterial	Infection
BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM .

HY-149064

Antituberculosis agent-9

Bacterial Infection

Antituberculosis agent-9 (Compound 5a) is an orally active antitubercular agent with an MIC of 0.5 μg/mL against H37Ra .
HY-146555

Antitubercular agent-14

Bacterial Infection

Antitubercular agent-14 (Compound 1) is an antitubercular agent with an MIC of 0.3 µg/mL against M. tuberculosis .

Antituberculosis agent-9	Bacterial	Infection
Antituberculosis agent-9 (Compound 5a) is an orally active antitubercular agent with an MIC of 0.5 μg/mL against H37Ra .

Antitubercular agent-14	Bacterial	Infection
Antitubercular agent-14 (Compound 1) is an antitubercular agent with an MIC of 0.3 µg/mL against M. tuberculosis .

HY-151598

Pks13-TE inhibitor 2	Bacterial	Infection
Pks13-TE inhibitor 2 (compound 32) is a 13-Thioesterase (Pks13-TE) inhibitor (IC₅₀=1.30 μM). Pks13-TE inhibitor 2 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0039-0.0078 μg/mL). Pks13-TE inhibitor 2 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB .

HY-151599

Pks13-TE inhibitor 3	Bacterial	Infection
Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC₅₀=1.55 μM). Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL). Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB .

HY-108941

Salicyl-AMS

Bacterial Infection

Salicyl-AMS is a mycobactin biosynthesis inhibitor which can also inhibit M. tuberculosis growth in vitro under iron-limited conditions.

Salicyl-AMS	Bacterial	Infection
Salicyl-AMS is a mycobactin biosynthesis inhibitor which can also inhibit M. tuberculosis growth in vitro under iron-limited conditions.

HY-146158

WX-081	Bacterial Potassium Channel Antibiotic	Infection
WX-081, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. WX-081 exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for agent susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. WX-081 also inhibits hERG channel with the IC50 of 1.89 μM.

HY-B0271S

Pyrazinamide-d3 Pyrazinecarboxamide-d₃; Pyrazinoic acid amide-d₃	Isotope-Labeled Compounds Bacterial Autophagy Antibiotic	Infection
Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].

HY-139654

α/β-Hydrolase-IN-1	Others	Infection
α/β-Hydrolase-IN-1 exhibits the best-in-class MICs of 50 μM (25 μg/mL) and 16 μM (8.4 μg/mL) against M. smegmatis and M. tuberculosis* H37Ra*, respectively.

HY-146374

Antibacterial agent 96	Bacterial	Infection
Antibacterial agent 96 (compound 4k) is a potent antibacterial agent. Antibacterial agent 96 shows antitubercular activity against agent-susceptible and multidrug-resistantMycobacterium tuberculosis (M. tuberculosis) strains. Antibacterial agent 96 shows toxicity to HepG2 and Vero cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2033

Chebulinic acid 1 Publications Verification	Infection Structural Classification Classification of Application Fields Combretaceae Source classification Phenols Polyphenols Terminalia chebula Retz. Plants Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Proton Pump
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-16566A

Kanamycin sulfate 5+ Cited Publications Kanamycin A sulfate	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Fields	Bacterial Antibiotic
Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

HY-N12600

Thiolopyrrolone A	Structural Classification Natural Products Microorganisms Marine natural products Source classification Marine microorganism	Bacterial
Thiolopyrrolone A (compound 1) exhibits antibacterial activities against BCG, M. tuberculosis and S. aureus with minimum inhibitory concentrations (MIC) of 10, 10 and 100 μg/mL, respectively .

HY-N3612

Communic acid (+)-Communic acid	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial Akt MMP
Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC₅₀ of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging .

HY-N11048

Amycolatopsin A	Infection Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields Cancer	Bacterial
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC₅₀ values of 0.4 µM and 4.4 µM, respectively .

HY-N2876

Anisofolin A	Structural Classification Monophenols Flavonoids Flavones Labiatae Source classification Phenols Plants Artemisia persica Boiss.	Parasite Bacterial
Anisofolin A is a flavonoid that can be isolated from Anisomeles indica. Anisofolin A has antimalarial activity (IC₅₀: 4.39 μM), and antimycobacterium activity (IC₅₀: 4.50 μM) against M. tuberculosis H37Ra .

HY-N10069

Bonducellin	Structural Classification Flavonoids Leguminosae Caesalpinia sappan L. Source classification Plants Other Flavonoids	Others
Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L) .

HY-N8060A

Orotidine 5′-monophosphate trisodium Orotidine monophosphate trisodium; Orotidylic acid trisodium	Alkaloids Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) .

Cat. No.	Product Name	Chemical Structure

HY-B0271S

Pyrazinamide-d3
Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].

HY-10844S

Pretomanid-d4
Pretomanid-d4 is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL[1][2].

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks